Statistical methodological limitations and improvement suggestions in the study of vitamin D deficiency and cardiovascular mortality after heart transplantation - 07/10/25
Doi : 10.1016/j.ahj.2025.08.015
Haiying Hu, BSc, Linjun Wang, BSc ⁎ 
Department of Clinical Laboratory, The Affiliated Yangming Hospital of Ningbo University, Yuyao People's Hospital of Zhejiang Province, Yuyao, Zhejiang, China
⁎ Corresponding author at: Linjun Wang, Department of Clinical Laboratory, The Affiliated Yangming Hospital of Ningbo University, Yuyao People's Hospital of Zhejiang Province, 800 Chengdong Road, Yuyao City 315400, Zhejiang Province, China. Department of Clinical Laboratory The Affiliated Yangming Hospital of Ningbo University Yuyao People's Hospital of Zhejiang Province 800 Chengdong Road Yuyao City Zhejiang Province 315400 China
Highlights |
• | Low EPV (4.9) risks unstable Cox model hazard ratios with 14 covariates. |
• | CAV mediation (26.5%) lacks robustness from limited event numbers. |
• | Penalized regression and sensitivity analyses could improve model reliability. |
Plan
© 2025
Elsevier Inc. Tous droits réservés.
Vol 291
P. 216-217 - janvier 2026 Retour au numéro
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