Diabetes mellitus is a global health concern, with complications such as peripheral neuropathy and peripheral arterial disease (PAD) leading to diabetic foot ulcers, infections, and amputations. Chronic limb-threatening ischemia, a severe form of PAD, further impairs healing and increases amputation risk. Limb-sparing procedures like partial foot amputations aim to preserve mobility and improve outcomes. Neuropathy contributes to unnoticed injuries and poor skin integrity, while abnormal foot biomechanics from deformities increase pressure points, promoting ulcer formation. Early diagnosis, proper wound care, and revascularization are crucial in preventing complications and improving quality of life for diabetic patients.