Artificial Intelligence in Endodontics/Robotics- Microrobotics in Endodontics: A Revolutionary Approach to Root Canal Treatment and Nanozymes - 16/10/25

Doi : 10.1016/j.cden.2025.05.002

Nadasinee Jaruchotiratanasakul, DDS ^a,^b,^c,^d, Hong Huy Tran, PhD ^c,^e,^f, Edward B. Steager, PhD ^b,^c,^g, Hyun Koo, DDS, MS, PhD ^b,^c,^e,^h, Bekir Karabucak, DMD, MS ^a,^⁎
^a Department of Endodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
^b Center for Innovation & Precision Dentistry, School of Dental Medicine, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA
^c Biofilm Research Laboratories, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
^d Department of Operative Dentistry and Endodontics, Faculty of Dentistry, Mahidol University, Bangkok 10400, Thailand
^e Department of Orthodontics, Division of Pediatric Dentistry and Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
^f Department of Chemical and Biomolecular Engineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA
^g GRASP Laboratory, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA
^h Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA

^∗Corresponding author.

Résumé

This article explores cutting-edge innovations in endodontic care, emphasizing the role of microrobotics and nanozymes in overcoming persistent challenges like biofilm eradication and effective root canal disinfection. Nanozyme-shelled microcapsules and advanced robotic systems enable precise navigation, biofilm removal, and therapeutic delivery in complex dental structures, reducing reinfection rates and improving treatment outcomes. While these technologies offer transformative potential, challenges—such as biocompatibility, fabrication complexities, and clinical integration—remain. This article highlights ongoing research and future opportunities to integrate these advancements into routine care, paving the way for minimally invasive, efficient, and regenerative approaches in endodontic therapy.

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Keywords : Nanozymes, Microrobotics, Robotics in endodontics, Root canal treatment, Advanced technology, Root canal disinfection