Anaphylaxis is a (frequently underdiagnosed) type 1 hypersensitivity reaction, and the astute clinician must remain vigilant to recognize it, especially in children. Myriad triggers may precipitate anaphylaxis. The multi-system manifestations are numerous and may be confused with other diagnoses. Timely treatment with appropriately dosed epinephrine is essential to prevent complications or recurrent symptoms. Clinicians may consider using antihistamines, steroids, beta-agonists, fluids, or even vasopressors. Once symptoms are mitigated, patients require epinephrine autoinjector prescriptions and education, and a clear anaphylaxis emergency plan. Close follow-up with primary care and/or an allergy specialist is prudent.