Post Void Residual and Bladder Capacity Predict Urinary Continence Following Holmium Laser Enucleation of the Prostate for Benign Prostatic Hyperplasia - 22/10/25

Doi : 10.1016/j.urology.2025.09.049

Feres Camargo Maluf ^a,^⁎ , William A. Pace ^b,^c, Lynn Leng ^b,^c, Pablo A. Suarez ^b,^c, Darren Chau ^b,^c, Udaybir Mann ^b, Maria C. Velasquez ^b, Kazumi Taguchi ^a, Joel T. Funk ^a, James E. Bryant ^a, Karishma Gupta ^a, Thomas Chi ^a
^a University of Alabama at Birmingham, Department of Urology. Birmingham, AL
^b University of California, San Francisco, Department of Urology. San Francisco, CA
^c University of California, San Francisco, School of Medicine. San Francisco, CA

^⁎Address correspondence to: Feres Camargo Maluf, MD, Department of Urology, University of Alabama at Birmingham, FOT 1120 1720 2nd Ave. S. Birmingham, AL 35294–3411.Department of Urology, University of Alabama at BirminghamFOT 1120 1720 2nd Ave. SBirminghamAL35294–3411

Sous presse. Épreuves corrigées par l'auteur. Disponible en ligne depuis le Wednesday 22 October 2025

ABSTRACT

Objective

To better understand and potentially predict transient urinary incontinence following Holmium laser enucleation of the prostate (HoLEP), we investigated whether preoperative urodynamic studies (UDS), the gold standard for assessing bladder physiology, can identify patients at higher risk for transient urinary incontinence.

Methods

We conducted a single-institution retrospective cohort study of patients who underwent UDS followed by HoLEP for BPH between 2017 and 2023. We collected data on baseline characteristics, UDS parameters, and perioperative outcomes. The primary outcome was urinary incontinence (UI) at 1, 3, 6, and 12 months post-surgery.

Results

Around 129 subjects were identified and univariate analysis demonstrated that postoperative UI rates were lower in patients with a preoperative post-void residual (PVR) greater than 250 mL when compared to those with a PVR ≤250mL at 3 months (33.3% vs 55.6%;P=.02) and 6 months (11.5% vs 39.2%; P<.01). Similarly, patients with a bladder capacity exceeding 600 mL experienced lower UI rates at 1 month (P=.01), 6 months (P<.01), and 12 months (P=.03) compared to those with a bladder capacity ≤600mL. Furthermore, adjusted analysis confirmed these findings that PVR >250 mL and bladder capacity >600 mL were associated with a 28% (95%CI [12.1%-43.3%]; P<.01) and 26% (95%CI [13.2%-39%]; P<.01) lower probability of UI at 6 months, respectively.

Conclusion

Adding baseline PVR and bladder capacity assessment to the preoperative evaluation may supplement counseling on protective factors for UI following HoLEP.

Le texte complet de cet article est disponible en PDF.