A broad spectrum of inflammatory and infiltrative conditions can affect the genitourinary (GU) system. Radiologists play a crucial role in diagnosing these disorders, and a strong understanding of these entities and their potential complications is essential. Imaging features are often key factors in identifying these conditions, assessing their severity, and guiding appropriate management. This review provides an overview of inflammatory and infiltrative disorders of the GU tract, focusing on their etiology, characteristic imaging findings, and potential complications to aid practicing radiologists in diagnosis.