Immune-Mediated Neuropathies Other Than Typical Chronic Inflammatory Demyelinating Polyradiculoneuropathy-Multifocal Motor Neuropathy, Autoimmune Nodopathies, Anti-Myelin Associated Glycoprotein Neuropathy, Chronic Inflammatory Sensory Polyradiculoneuropathy, and Chronic Ataxic Neuropathy with Ophthalmoplegia, M-Protein, Agglutinin, and Disialosyl Antibodies - 27/10/25

Doi : 10.1016/j.ncl.2025.05.017

Amro M. Stino, MD ^a,^⁎ , Mazen M. Dimachkie, MD ^b,^c,^d, Jonathan S. Katz, MD ^e, Richard J. Barohn, MD ^f
^a Department of Neurology, Peripheral Nerve Center, University of Michigan, F2647 UH South SPC 5223, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA
^b Department of Neurology, University of Kansas Medical Center, 4350 Shawnee Mission Parkway, Fairway, KS 66205, USA
^c Institute for Neurological Discoveries, School of Medicine
^d Neuromuscular Division, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA
^e Forbes Norris ALS Research and Treatment Center / Sutter Health Neurosciences, 1100 Van Ness Avenue, Floor 6, San Francisco, CA 94109, USA
^f University of Missouri School of Medicine, University of Missouri Medical Center, 1 Hospital Drive, Columbia, MO 65212, USA

^∗Corresponding author. Department of Neurology, University of Michigan, F2647 UH South, SPC 5223, 1500 E. Medical Center Drive, Ann Arbor, MI 48109.Department of NeurologyUniversity of MichiganF2647 UH SouthSPC 52231500 E. Medical Center DriveAnn ArborMI48109

Résumé

A pattern recognition approach to autoimmune polyneuropathies is fundamental to an evidence-based, efficient, and cost-effective approach to the accurate diagnosis of such chronic inflammatory demyelinating polyneuropathy mimickers as multifocal motor neuropathy, autoimmune nodopathies, anti-myelin associated glycoprotein neuropathy, chronic inflammatory sensory polyradiculoneuropathy, and chronic ataxic neuropathy with ophthalmoplegia, M-protein, agglutinin, and disialosyl antibodies. Increased understanding of the IgG4 and IgG3 mediated autoimmune nodopathies represents an exciting advance in our pathomechanistic understanding of immune mediated polyneuropathy that defies the traditional axonal vs demyelinating construct, and rather, reflects targeted dysfunction of the node of Ranvier.

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Keywords : Anti-myelin associated glycoprotein neuropathy, Autoimmune nodopathies, Chronic inflammatory sensory polyradiculoneuropathy, Chronic ataxic neuropathy with ophthalmoplegia, M-protein, Agglutinin, Disialosyl antibodies