Nanodentistry involves the use of nanoparticles (NPs) and nanomaterials to innovate and enhance dental treatment modalities. By modifying materials at the nanoscale, their physicochemical and biologic properties are significantly improved, offering superior antimicrobial, regenerative, and diagnostic capabilities. These advancements have demonstrated their broad utility across preventive and restorative dentistry, periodontics, prosthodontics, orthodontics, and oral cancer therapy. This article highlights key scientifically researched NPs in dentistry, their concerns regarding biocompatibility, and the need for further investigation before these technologies can be widely adopted in clinical practice.