Dental implants are a predictable and effective modality for replacing missing teeth, with high long-term survival rates. However, implant failure can occur due to biologic, mechanical, or patient-related factors. Risk factors, such as smoking, uncontrolled-systemic diseases (e.g. diabetes), certain medications, and a history of periodontitis, must be screened and identified during the treatment planning phase. Although absolute contraindications are rare, thorough patient evaluation and coordination with the patient’s physician are critical for optimal outcomes.