Status epilepticus (SE) is a life-threatening neurological emergency defined by prolonged seizure activity or seizure activity without a return to baseline. SE can lead to permanent neuronal injury, and it is crucial that it be recognized as soon as possible. Management of SE follows a stepwise approach, with benzodiazepines first-line, followed by antiseizure drugs, and finally with anesthetics. Assessing airway status, along with checking for hypoglycemia and pregnancy status in reproductive-age women, are imperative. Nonconvulsive SE can be difficult to diagnose and requires EEG for detection. Special considerations apply for cases of SE in pregnant, elderly, and immunocompromised patients.