In this article, we aim to provide an in-depth review of the 2 primary ablative therapies, radiofrequency ablation and cryotherapy, for the treatment of dysplastic Barrett’s esophagus (BE). Specifically for cryotherapy, the article will focus on liquid nitrogen spray cryotherapy and cryoballoon ablation. For each ablative modality, we will discuss the mechanisms of action, technical aspects, indications, patient selection, treatment protocols, efficacy, safety, and outcomes of both therapies. Additionally, we will provide an overview of the role of endoscopic eradication therapy within the broader management strategy of BE, including pretreatment assessment, patient counseling, and long-term surveillance.