Subretinal Hyperreflective Material, Atrophy, and Intraretinal Fluid in Pachychoroid Neovasculopathy - 18/11/25
, Ho Ra 1, 2, Seung Hoon Lee 1, 2, Chui Ming Gemmy Cheung 3, 4, Won Ki Lee 5Highlights |
• | Subretinal hyperreflective material (SHRM) in pachychoroid neovasculopathy (PNV) has not been thoroughly investigated. |
• | In this study, we evaluated the associations between SHRM, atrophy, and intraretinal fluid (IRF) in PNV eyes undergoing anti-vascular endothelial growth factor therapy. |
• | SHRM was significantly associated with the development of atrophy, fibrosis, and IRF. Notably, most SHRM regressed completely after treatment, often leaving areas of atrophy. |
Résumé |
Purpose |
To assess the association between subretinal hyperreflective material (SHRM), atrophy, and intraretinal fluid (IRF) in pachychoroid neovasculopathy (PNV).
Design |
Retrospective observational study.
Subjects |
A total of 120 eyes diagnosed with PNV and treated with antivascular endothelial growth factor for more than 1 year.
Methods |
Central macular thickness (CMT), best-corrected visual acuity (BCVA), and the presence of SHRM, atrophy, fibrosis, subretinal fluid (SRF), and IRF were assessed at baseline, 3 months, and 1 year. SHRM and atrophy areas were also quantitatively measured. Comparisons were made between eyes with SHRM (SHRM [+]) and without SHRM (SHRM [−]) at baseline.
Main Outcome Measures |
Incidence and area of SHRM, development of atrophy and fibrosis, presence and resolution of IRF and SRF, changes in CMT and BCVA.
Results |
At baseline, 57 eyes (47.5%) exhibited SHRM, which regressed in 85% after 1 year. Atrophy developed in 40% of eyes at 1 year, with 83.3% occurring in SHRM (+) eyes. Fibrosis was observed in 21.7% of eyes, with 92.3% in SHRM (+). IRF was more prevalent in SHRM (+) (all P ≤ .010) and showed limited resolution compared with SRF (McNemar P = .099 vs P < .001). SHRM (+) eyes had thinner CMT and worse BCVA.
Conclusions |
SHRM at baseline was associated with the development of atrophy, fibrosis, and IRF in PNV. Although most SHRM regressed after treatment, it frequently resulted in residual atrophy.
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| ☆ | This invited article was submitted as part of the Medical and Surgical Retina Update Joint Virtual Special Issue with the Asia-Pacific Journal of Ophthalmology (APJO). |
Vol 280
P. 472-480 - décembre 2025 Retour au numéro
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