Systemic immune profiling identifies elevated mas-related G-coupled receptor membrane X2 (MRGPRX2) with a distinct inflammatory signature in chronic pruritus of unknown origin - 19/11/25
Doi : 10.1016/j.jaad.2025.08.006
Yagiz Matthew Akiska, BSE a, b, Aaron Bao, BS a, b, Davies Gage, BS a, b, Shahin Shahsavari, BA a, b, Selina M. Yossef, BA a, b, c, Louis J. Born, MD, PhD a, b, Kavita Vats, PhD a, b, Madan M. Kwatra, PhD c, Shawn G. Kwatra, MD a, b, ⁎ 
a Department of Dermatology, University of Maryland School of Medicine, Baltimore, Maryland
b Maryland Itch Center, University of Maryland School of Medicine, Baltimore, Maryland
c Department of Anesthesiology, Duke University School of Medicine, Durham, North Carolina
∗ Correspondence to: Shawn G. Kwatra, MD, Joseph W. Burnett Professor and Chair, Department of Dermatology, University of Maryland School of Medicine, Director, Maryland Itch Center, Director, Maryland Itch Fellowship Program, 419 W. Redwood St, Baltimore, MD 21201-1509 Joseph W. Burnett Professor and Chair Department of Dermatology University of Maryland School of Medicine Director Maryland Itch Center Director Maryland Itch Fellowship Program 419 W. Redwood St Baltimore MD 21201-1509
Key words : atopic dermatitis, chronic pruritus of unknown origin, chronic pruritus, CPUO, cytokine profilingimmune endotypes, immunology, mast cells, MRGPRX2
| Funding sources: SGK is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number K23AR077073. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Part of this work was also funded by grants to SGK from the Dermatology Foundation Career Development Award. |
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| Patient consent: All participants provided informed consent, and the study was conducted in accordance with IRB guidelines. |
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| IRB approval status: This study was approved by the institutional review board (IRB00119007). |
© 2025
Publié par Elsevier Masson SAS.
Vol 93 - N° 6
P. 1566-1568 - décembre 2025 Retour au numéro
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