Ultraviolet-induced fluorescent dermoscopy for the diagnosis of skin tumors: A multicenter study - 21/11/25

Doi : 10.1016/j.jaad.2025.10.131

Cristian Navarrete-Dechent, MD ^a,^b,^c,^⁎ , Pawel Pietkiewicz, MD, PhD ^m, Alvaro Abarzua-Araya, MD ^a,^b, Rosario Agüero, MD, MSc ^a, Stephen W. Dusza, DrPH ^e, Julien Anriot, MD ^f,^g, Pablo Vargas-Mora, MD ^h, Javiera Garcés, MD ^a, Sofía Villagrán, MD ^a, Sergio Bustos, MD ^a, Sebastián González-Valdés, MD ^a, Samuel Ibañez, MD ^a, Manuela Boleira, MD ⁱ, Natalia Jaimes, MD ^j,^k, David Swanson, MD ^l, Leonel Hidalgo, MD ^a, Katherine Droppelmann, MD, MSc ^a,^b, Consuelo Cardenas, MD ^a,^b, Pablo Uribe, MD, PhD ^a,^b, Ashfaq A. Marghoob, MD ^d

^a Department of Dermatology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile

^b Melanoma and Skin Cancer Unit, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile

^c Millennium Institute for Intelligent Healthcare Engineering, Santiago, Chile

^d Surgical Oncology and General Surgery Clinic I, Greater Poland Cancer Center, Poznan, Poland

^e Department of Medicine, Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York

^f Dermatologie, Centre Léon Bérard, Lyon, France

^g Université Claude Bernard Lyon 1, Villeurbanne, France

^h Department of Dermatology, Facultad de Medicina, Universidad de Chile, Santiago, Chile

ⁱ Department of Dermatology, Policlinica Geral do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil

^j Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida

^k Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida

^l Department of Dermatology, Mayo Clinic Arizona, Scottsdale, Arizona

^m Prisca Sapientia Institute, Zurich, Switzerland

^∗ Correspondence to: Cristian Navarrete-Dechent, MD, Department of Dermatology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Diagonal Paraguay 362, 6th floor, Santiago 8330077, Chile. Department of Dermatology Escuela de Medicina Pontificia Universidad Católica de Chile Diagonal Paraguay 362 6th floor Santiago 8330077 Chile

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Abstract

Background

Ultraviolet-induced fluorescent dermoscopy (UVFD) is a novel dermoscopic technique that has shown potential to improve diagnostic accuracy for select conditions in small case series. However, its performance has not yet been assessed in a large cohort of cutaneous tumors.

Objective

To evaluate the role of UVFD in cutaneous tumors.

Methods

This retrospective, multicenter study included consecutive lesions assessed at 3 tertiary care clinics in Chile, France, and Poland. Standard polarized dermoscopic images and UVFD images were independently reviewed by 2 expert dermoscopists, with consensus evaluation. Established dermoscopic criteria, as well as border definition and the presence of “ochre color” under UVFD, were specifically assessed.

Results

Five hundred fifty-one lesions were included. The most frequent diagnosis was basal cell carcinoma (28.2%), followed by melanocytic nevus (18.6%) and melanoma (12.8%). Keratin, comedo-like openings, and fissures and ridges were better seen under UVFD. The border definition of lesions was also better seen under UVFD. Ochre color was seen under UVFD mostly in invasive melanomas.

Limitations

Retrospective study. Some diagnoses were underrepresented.

Conclusion

UVFD enhances specific keratin-related dermoscopic structures and colors. It also provides for better border delineation and may help in identifying invasive melanomas via the presence of ochre color.

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Key words : basal cell carcinoma, dermatoscopy, dermoscopy, fluorescence, melanoma, seborrheic keratosis, skin cancer, ultraviolet

Abbreviations used : BCC, MAY, UVFD

Plan

Introduction

Patients and methods

Dermoscopy imaging protocol

Clinical and biopsy data

	Funding sources: Drs Marghoob and Dusza were supported in part by Memorial Sloan Kettering Cancer Center's NIH / National Cancer Institute Cancer Center support grant P30 CA008748 .
	Patient consent: Patients have given consent for publication of images.
	IRB approval status: Approved by Pontificia Universidad Catolica de Chile.