Bioactive elastin-like-recombinamer (ELR) membranes guide bone regeneration in rabbit critical size calvarial defects - 23/11/25

Doi : 10.1016/j.jormas.2025.102514

Vasiliki P. Koidou ^a,^⁎ , Shakeel Shahdad ^b, Mital Patel ^b, Stuart Lanham ^c, Shaun Peggrem ^d, Richard Oreffo ^c, José Carlos Rodriguez-Cabello ^e, Alvaro Mata ^f,^g,^h, Sherif Elsharkawy ⁱ
^a Centre for Oral Clinical Research, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
^b Oral Rehabilitation & Implantology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
^c Bone and Joint Research Group, University of Southampton, Southampton, UK
^d School of Engineering and Materials Science, Queen Mary University of London, London, UK
^e G.I.R. Bioforge, University of Valladolid, LADIS, CIBER-BBN, Valladolid, Spain
^f School of Pharmacy, University of Nottingham, Nottingham, UK
^g Biodiscovery Institute, University of Nottingham, Nottingham, UK
^h Department of Chemical and Environmental Engineering, University of Nottingham, Nottingham, UK
ⁱ Centre for Oral, Clinical, and Translational Sciences, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK

^⁎Corresponding author at: Centre for Immuno-Biology & Regenerative Medicine, Barts and The London School of Medicine and Dentistry, Queen Mary University of London (QMUL), Turner Street, London, E1 2A.Centre for Immuno-Biology & Regenerative MedicineBarts and The London School of Medicine and DentistryQueen Mary University of London (QMUL)Turner StreetLondonE1 2A

Abstract

Objectives

To examine the effectiveness of non-mineralised and pre-mineralised elastin-like recombinamer (ELR) membranes in guided bone regeneration (GBR) in a pre-clinical rabbit model.

Materials and Methods

Three pre-mineralised ELR membranes (D1, D2 and D8) and a non-mineralised (D0) membrane, along with a collagen membrane (C+) and an empty defect were randomly allocated in rabbit calvarial defects of critical size. Four weeks post-implantation the animals were euthanized and bone fill was assessed using micro CT and histological evaluation.

Results

Using micro CT, all ELR membranes led to similar bone density, as unassisted healing and healing using a resorbable collagen membrane. A trend for superior bone fill with the D2 pre-mineralised ELR membrane was observed. Histologically, at this early time-point the ELR membranes successfully guided GBR in the defects, similarly to the control collagen membrane, and additionally led to the formation of a thin woven bone layer at the top of the cranial defect bridging between the margins of the defect.

Conclusions

As early as 4 weeks post-implantation, the ELR membranes successfully guided bone regeneration in this rabbit critical size calvarial model and a trend for superior regeneration was observed with pre-mineralised for 2 days ELR membranes. The ELR membranes led to the formation of a bony bridge parallel to the membrane suggesting bioactivity beyond occlusion of the defect.

Clinical Relevance

These bioactive alloplastic membranes may succesfully serve as alternatives to allogenic membranes in guided bone regeneration.

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Keywords : Bone regeneration, Animal model, Membranes, Guided bone regeneration

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Vol 126 - N° 6S

Article 102514- décembre 2025 Retour au numéro

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Bioactive elastin-like-recombinamer (ELR) membranes guide bone regeneration in rabbit critical size calvarial defects - 23/11/25

Abstract

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Materials and Methods

Results

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Clinical Relevance

Plan

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