Sex differences in Acinetobacter baumannii infections: A comprehensive analysis of antibiotic resistance patterns in Hebei Province, China - 24/11/25
Résumé |
Background |
To investigate the clinical distribution and antimicrobial resistance patterns of Acinetobacter baumannii in Hebei Province, with a focus on sex-based differences.
Methods |
Surveillance data from 45 hospitals across Hebei Province were retrospectively analyzed from January 2020 to December 2022. Isolates were stratified by patient sex, age group, and specimen type. Data were processed using WHONET 5.6 and GraphPad Prism 8.4.0.
Results |
A total of 27,754 A baumannii strains were collected, with 84.0% isolated from respiratory specimens. Male patients accounted for 65.9% of cases, nearly double that of females. Isolates from males showed higher resistance rates to β-lactamase inhibitor combinations, fluoroquinolones, cephalosporins, aminoglycosides, and carbapenems, particularly in the 15 to 50-year age group. Sex-related differences in resistance were also influenced by infection site.
Conclusions |
Marked sex differences exist in A baumannii infection and antibiotic resistance patterns in Hebei Province, especially among males of reproductive age. These findings highlight the potential role of sex-specific factors in antimicrobial resistance and may inform targeted prevention and treatment strategies.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Respiratory specimens made up 84% of Acinetobacter baumannii isolates in Hebei, China. |
• | Male patients had nearly twice as many isolates as female patients. |
• | Resistance rates were higher in males, especially those aged 15 to 50 years. |
• | Sex differences in resistance varied by infection site and age group. |
Key Words : Acinetobacter baumannii , Antibiotic resistance, Carbapenem resistance
Plan
| Conflicts of interest: None to report. |
|
| Funding/support: This study was supported by the Hebei Natural Science Foundation [grant number H2022206358], the Foundation of Hebei Provincial Department of Finance [grant number 361004], the Hebei Province County-level Comprehensive Hospital Suitable Health Technology Promotion Project [grant number 20200018], and the Qingdao Medical and Health Research Project [grant number 2024-WJKY025]. |
Vol 53 - N° 12
P. 1300-1304 - décembre 2025 Retour au numéro
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