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Effectiveness of Multilevel Implementation Strategies for Autism Interventions: Outcomes of Two Linked Implementation Trials - 26/11/25

Doi : 10.1016/j.jaac.2025.01.003 
Lauren Brookman-Frazee, PhD a, b, , Anna S. Lau, PhD c, Scott C. Roesch, PhD d, Allison Jobin, PhD b, e, Colby Chlebowski, PhD b, d, Melissa Mello, PsyD f, g, Barbara Caplan, PhD h, Sylvie Naar, PhD i, j, Gregory A. Aarons, PhD a, b, Aubyn C. Stahmer, PhD f, g
a University of California San Diego 
b Child and Adolescent Services Research Center, San Diego 
c University of California Los Angeles 
d San Diego State University 
e California State University San Marcos 
f University of California, Davis 
g UC Davis MIND Institute, Sacramento 
h California State University, Long Beach 
i Center for Translational Behavioral Research, Tallahassee 
j Florida State University 

Correspondence to Lauren Brookman-Frazee, PhD, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0812 University of California 9500 Gilman Drive La Jolla San Diego CA 92093-0812

Abstract

Objective

This study tests the effectiveness of leader- and provider-level implementation strategies to implement evidence-based interventions (EBIs) in 2 of the service systems caring for autistic children. The TEAMS Leadership Institute (TLI) targets implementation leadership and climate, and TEAMS Individualized Provider Strategy (TIPS) targets provider motivation and engagement.

Method

A cluster randomized hybrid type 3 implementation-effectiveness trial tested the effects of the implementations strategies when paired with AIM HI (An Individualized Mental Health Intervention for Autism) in mental health programs (study 1) and CPRT (Classroom Pivotal Response Teaching) in classrooms (study 2). The combined sample included 65 programs/districts across 4 training cohorts (2018-2019 to 2020-2021). Organizations were randomized to receive a leader-level strategy, provider strategy, both strategies, or neither strategy (EBI provider training only). Leader and provider participants were recruited from enrolled programs/districts, and child participants were recruited from providers’ caseloads or classrooms. Data from a total of 387 providers (mean age = 36.39 years; 91% female participants; 30% Latino/a/x participants) and 385 children (mean age = 8 years; 80% male participants; 45% Latino/a/x participants) were analyzed. Outcomes were assessed over 6 months. Provider outcome measures included provider EBI certification and observed EBI fidelity. Clinical outcome measures included the Eyberg Child Behavior Inventory (ECBI) (study 1) and the Pervasive Developmental Disorder Behavior Inventory (PDD-BI) (study 2). Outcomes were analyzed using intent-to-treat models.

Results

There was no significant effect of TLI on EBI Certification. TLI was associated with significantly higher EBI fidelity compared to non-TLI (B = 0.37, p = .04). Moreover, a statistically significant TLIxTime interaction was found for child outcome T scores (B = −10.47, p = .03), with a significant reduction in T scores across time only for those in the TLI condition. There were no significant effects of TIPS on any outcomes.

Conclusion

Findings support the effectiveness of leader-focused strategies to promote implementation and clinical outcomes of autism EBIs in multiple public service systems and for multiple EBIs.

Plain language summary

Although many evidence-based interventions have been developed for autistic children, they are not routinely delivered in usual-care services. This randomized controlled trial tested two implementation strategies, one focused on leadership and climate, the other focused on provider motivation and engagement. These implementation strategies were paired with two different autism interventions (An Individualized Mental Health Intervention for Autism [AIM HI], and Classroom Pivotal Response Teaching [CPRT]). The study took place in 65 mental health programs and school districts in California with 387 providers and 385 child participants. The authors found that the leadership and climate-focused implementation strategy, but not the provider-focused strategy, increased providers’ use of the autism interventions and improved child outcome over 6 months. The study highlights the important role of organizational and district leaders in improving intervention delivery and child outcomes in usual care.

Clinical trial registration information

Translating Evidence-based Interventions for ASD: Multi-Level Implementation Strategy (TEAMS); NCT03380078 .

Le texte complet de cet article est disponible en PDF.

Key words : autism, evidence-based autism interventions, implementation strategies, implementation trial, leadership strategies


Plan


  Research reported in this publication was supported by grants R01MH111950 (LBF) and R01MH111981 (ACS) from the National Institute of Mental Health . Additional institutional support was provided by P50MH126231 (LBF) and P50DH103526 (ACS). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
  Data Sharing: Data can be accessed through nda.nih.gov/ . Deidentified participant data will be made available with the publication per NDA Guidelines.
 Disclosure: Lauren Brookman-Frazee, Anna S. Lau, Scott C. Roesch, Allison Jobin, Colby Chlebowski, Melissa Mello, Barbara Caplan, Sylvie Naar, Gregory A. Aarons, and Aubyn C. Stahmer have reported no biomedical financial interests or potential conflicts of interest.


© 2025  American Academy of Child and Adolescent Psychiatry. Publié par Elsevier Masson SAS. Tous droits réservés.
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Vol 64 - N° 12

P. 1386-1400 - décembre 2025 Retour au numéro
Article précédent Article précédent
  • The Rapid Autism Assessment: Reducing Barriers to Behavioral Intervention Services
  • Yumi Kovic, Gabrielle D. Dallas, Joanne L. Andrade, Lindsay A. Lloveras, Kerri P. Peters, Takahiro Soda
| Article suivant Article suivant
  • Intergenerational Impacts of Historical Trauma on Contemporary Depression Symptoms Among Indigenous Communities
  • Ashley B. Cole, Kelley J. Sittner, Trisha Bruyere, Melissa L. Walls

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