Association Between Omega-3 Supplement Use and Cognitive Function in Korean Older Adults: An 8-Year Longitudinal Cohort Study - 27/11/25
, Myoung-Nam Lim c, Ji Won Han d, Jong Bin Bae d, Tae Hui Kim e, Kyung Phil Kwak f, Bong Jo Kim g, Shin Gyeom Kim h, Jeong Lan Kim i, Seok Woo Moon j, Joon Hyuk Park k, Seung-Ho Ryu l, Dong Woo Lee m, Seok Bum Lee n, Jung Jae Lee n, Dong Young Lee o, p, Ki Woong Kim p, q, r, Jin Hyeong Jhoo a, s, ⁎
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Highlights |
• | This 8-year longitudinal cohort study investigated the association between O3FA supplementation and cognitive performance among community-dwelling older adults in South Korea. |
• | O3FA supplement use was significantly associated with better maintenance of CERAD-K[N] scores over time. |
• | Long-term (≥2 follow-ups; approximately ≥4 years) O3FA supplementation was associated with preserved global and memory cognitive performance over 8 years compared with non-users. |
Abstract |
Objectives |
South Korea has a relatively high baseline omega-3 fatty acids (O3FA) status due to dietary patterns. However, evidence on additional benefits of O3FA supplementation remains limited. This study examined the 8-year longitudinal effects of O3FA supplement use on cognitive performance among community-dwelling older adults in South Korea.
Design |
Prospective longitudinal cohort study.
Setting and participants: Data were from the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD). A total of 4,949 adults aged ≥60 years (mean age = 69.55 ± 6.56; 44.2% men) were included, and 2,053 completed the 8-year follow-up (2010–2012 to 2018–2020).
Measurements |
O3FA supplement use was assessed through structured questionnaires on regular intake of omega-3 or fish oil supplements. Cognitive performance was assessed using the Korean version of Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet Neuropsychological Assessment Battery (CERAD-K[N]), and total and memory domain scores were analyzed. Longitudinal changes were examined using repeated measures analysis of covariance and linear mixed-effects models (LMMs; unweighted and weighted), adjusting for potential covariates.
Results |
Over the 8 years, CERAD-K[N] (t = −2.686, p = .007) and memory domain (t = −4.026, p < .001) scores significantly improved among O3FA users. In the weighted LMM, significant time × supplement duration interactions were observed (CERAD-K[N]: β = 2.398, 95% CI 1.207–3.589, p < .001; memory: β = 1.050, 95% CI 0.643–1.456, p < .001), indicating greater improvement in long-term users.
Conclusion |
O3FA supplement use was associated with better maintenance of cognitive function over eight years. These findings suggest a potential role of O3FA supplementation in supporting cognitive health during aging.
Le texte complet de cet article est disponible en PDF.Keywords : Fatty acids, Omega-3, Cognitive dysfunction, Dietary supplements, Aged, Cohort studies, Longitudinal studies
Plan
Vol 30 - N° 1
Article 100739- janvier 2026 Retour au numéro
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