Hypocalcemia following total thyroidectomy remains a clinical challenge, often leading to preventable readmissions. Standardized PTH-based protocols offer a structured approach to postoperative management. This study examines institutional variations in such protocols and evaluates their effectiveness in minimizing unnecessary hospital visits.

A detailed search of published Parathyroid Hormone (PTH) based protocols at various institutions was conducted across Pubmed, Web of Science, Embase and Scopus. Variables such as mean hospital stay, PTH and calcium thresholds, supplementation guidelines, discharge criteria, ED visits and hospital readmissions were collected. This systematic review was PROSPERO registered with the ID CRD42024615865.

Of 1178 studies screened, 10 met inclusion criteria. Most protocols recommended PTH measurement within 4 ​h postoperatively, without routine postoperative calcium testing. Risk stratification typically used thresholds of 10–15 ​pg/mL, with some adopting tiered PTH categories. Effective protocols avoided supplementation in low-risk patients while standardizing calcium carbonate (1000 ​mg TID) ​± ​calcitriol (0.25–0.5 mcg BID) for medium/high-risk patients. Severe or refractory hypocalcemia was managed with intravenous calcium ​± ​magnesium. Follow-up was typically within 1–4 weeks, with same-day discharge feasible in select low-risk patients. Reported readmission rates ranged from 0 to 7.0 ​%, with most <1 ​%.

PTH-based protocols reduce readmissions after total or completion thyroidectomy by combining early PTH measurement, defined risk thresholds, selective supplementation, and timely follow-up. Adoption of these shared components across institutions could minimize unnecessary supplementation, improve safety, and standardize care.