Are there gender differences in adverse drug reactions to levodopa? A real-world safety comparison in the global pharmacovigilance database - 10/12/25
Summary |
Background |
Gender differences were reported in Parkinson's disease as well as in drug effects in general.
Objective |
The study was performed to investigate putative gender differences in levodopa-related adverse drug reactions (ADRs).
Methods |
Using Vigibase®, the global pharmacovigilance database, all ADRs reports with levodopa between 01/01/2000 and 31/12/2024 in adults were included. The main levodopa (motor and non-motor) ADRs were compared between women and men. Results are presented as reporting odds ratios (ROR) with their 95% confidence interval.
Results |
Among 2887 ADRs with levodopa, the reporting risk in women was significantly higher for dyskinesia (ROR = 1.31 [1.00–1.71]), dystonia (1.41 [1.03–1.93]), nausea-vomiting (2.08 [1.45–2.99]), and significantly lower for hypersexuality (0.10 [0.02–0.42]), dopamine dysregulation syndrome (0.32 [0.14–0.73]) pathological gambling (0.33 [0.14–0.76]) and all ADRs in general (0.48 [0.45–0.52]), with no difference for other ADRs.
Conclusion |
This study shows gender-related differences for not only motor (dyskinesia, dystonia) but also non-motor levodopa ADRs.
Le texte complet de cet article est disponible en PDF.Keywords : Levodopa, Gender, Dyskinesia, Dystonia, Hallucinations, Confusion, Dopamine dysregulation symptoms
Plan
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