Duchenne muscular dystrophy (DMD) is a severe, progressive neuromuscular disorder characterized by muscle degeneration and weakness, leading to significant physical disability and multisystem complications. The management of DMD requires a coordinated, multidisciplinary approach to address the evolving needs of patients from childhood through adulthood, with a focus on patient quality of life. Early diagnosis and proactive interventions are critical to optimizing outcomes and may include physical therapy, respiratory support, cardiac monitoring, and orthopedic care. In children, the focus is on preserving mobility, managing scoliosis, preventing cardiac and respiratory complications, and ensuring access to education and psychosocial support. As patients transition to adulthood, the challenges shift to maintaining independence, managing advanced respiratory and cardiac complications, and addressing vocational and social integration. Transition programs must be carefully planned to bridge pediatric and adult care systems, ensuring continuity and minimizing gaps in care. Adult care involves specialized teams to manage complex medical needs, including advanced respiratory support, cardiomyopathy, and palliative care. Anticipatory directives play a crucial role in aligningmedical interventions with patient and family preferences, particularly in advanced stages of the disease. This article outlines the principles of multidisciplinary care for DMD, emphasizing the importance of tailored interventions at each life stage, the challenges of transition, and the ethical considerations of anticipatory planning. By integrating medical, psychosocial, and rehabilitative strategies, healthcare providers can improve the quality of life and longevity of individuals with DMD.