Prognosis of central venous catheter-related Candida infection during hospitalization in conventional medical or surgical wards: A 13-year retrospective cohort study - 24/12/25
, Arthur Hacquin b, Stéphane Valot c, Mathieu Blot a, d, Lionel Piroth a, e, Thibault Sixt aHighlights |
• | Catheter-related Candida infections in conventional wards were associated with ICU transfer or 30-day mortality in approximately one-third of cases. |
• | Non-albicans Candida species represented a substantial proportion of isolates, consistent with recent epidemiological trends. |
• | Age over 60 years, qSOFA ≥2, and septic shock appeared more frequently among patients with an unfavorable outcome. |
• | Positive mannan antigen and/or antibody assays were more commonly observed in patients with poor clinical outcomes, suggesting a potential prognostic value. |
Abstract |
Objectives |
While catheter-related Candida infections in intensive care settings are well-described, data from conventional medical or surgical wards remain limited. This study aims to identify the clinical characteristics and prognostic factors of catheter-related Candida infections in such settings.
Methods |
We conducted a retrospective single-center cohort study from 2008 to 2022, including patients with confirmed catheter-related Candida infection. Diagnosis was based on a positive central blood culture, along with either a positive peripheral blood culture, local inflammatory signs, or radiological signs suggesting catheter-related candidemia. The main outcome was either transfer to the intensive care unit or death within 30 days.
Results |
Following a univariate analysis, 15 (30 %) patients among a total of 50 had an unfavorable outcome: eight (16 %) were transferred to the intensive care unit, and seven (14 %) died within 30 days. Poor outcome was associated with age over 60 years, clinical severity, and positive mannan biomarkers.
Conclusion |
Catheter-related Candida infections in non-critical care settings are associated with significant morbidity and mortality. Fungal biomarkers may hold clinically relevant prognostic value, necessitating further investigations.
Le texte complet de cet article est disponible en PDF.Keywords : Central venous catheter, Candidemia, Prognostic factors, Fungal biomarkers, Antifungal therapy
Abbreviations : CVC , ICU , PMSI , BDG , ELISA , IQR , ACCI , qSOFA , CoNS , IDSA , ECMM
Plan
Vol 56 - N° 1
Article 105227- janvier 2026 Retour au numéro
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