Understanding IgE-mediated autoimmunity and autoallergy - 05/01/26

Doi : 10.1016/j.jaci.2025.10.025

Sherezade Moñino-Romero, PhD ^a,^b, Inge Kortekaas Krohn, PhD ^c,^d, Yi-Kui Xiang, MD ^a,^b,^e, Sabine Altrichter, MD ^a,^b,^f,^g, Katrine Baumann, PhD ^h,ⁱ, Hafsa Belasri, MSc ^c,^d, Monique Butze, MSc ^a,^b,ⁱ, Shauni de Vriese, MSc ^c,^d, Stefan Frischbutter, PhD ^a,^b, Jan Gutermuth, MD ^c,^d, Emek Kocatürk, MD ^a,^b,^j, Paolo Maria Matricardi, MD ^a,^b,^k, Melba Muñoz, MD ^a,^b, Laurent L. Reber, PhD ^l, Jörg Scheffel, PhD ^a,^b, Per Stahl Skov, PhD ^h,^m, Carolin Steinert, MSc ^a,^b,ⁿ, Nicolas Charles, PhD ^o, Pavel Kolkhir, MD ^a,^b,^⁎

^a Institute of Allergology, Charité–Universitätsmedizin Berlin, a corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

^b Department of Immunology and Allergology, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Berlin, Germany

^c Vrije Universiteit Brussel (VUB), Skin Immunology & Immune Tolerance (SKIN) Research Group, Laarbeeklaan 103, 1090, Brussels, Belgium

^d Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Department of Dermatology, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium

^e Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China

^f Department of Dermatology and Venerology, Kepler University Hospital Linz, Linz, Austria

^g Center for Medical Research, Johannes Kepler University Linz, Linz, Austria

^h RefLab ApS, Hvidovre, Denmark

ⁱ Department of Biochemistry and Biology, University of Potsdam, Potsdam, Germany

^j Department of Dermatology, Bahcesehir University School of Medicine, Istanbul, Turkey

^k Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité–Universitätsmedizin Berlin, a corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

^l Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1291, Centre National de la Recherche Scientifique (CNRS) UMR5051, University of Toulouse, Toulouse, France

^m Department of Dermatology and Allergy Center, Odense Research Center for Anaphylaxis (ORCA), Odense University Hospital, Odense, Denmark

ⁿ Department of Biology, Chemistry and Pharmac, Freie Universität Berlin, Berlin, Germany

^o Centre de Recherche sur l’Inflammation, INSERM UMR1149, CNRS EMR8252, Inidex Infibrex, Faculté de Médecine site Bichat, Université Paris Cité, Paris, France

^∗ Corresponding author: Pavel Kolkhir, MD, Charité–Universitätsmedizin Berlin, Institute of Allergology IFA, Fraunhofer ITMP Immunology and Allergology IA, Krahmerstraße 1/Hindenburgdamm 27, 12203 Berlin, Germany. Charité–Universitätsmedizin Berlin Institute of Allergology IFA Fraunhofer ITMP Immunology and Allergology IA Krahmerstraße 1/Hindenburgdamm 27 Berlin 12203 Germany

Abstract

Chronic inflammatory diseases affect millions of people and are associated with considerable clinical, human, and economic burden. Available treatments have limitations; some are toxic, or they may prevent disease symptoms without affecting pathogenic drivers and disease course. Recent progress in the understanding of chronic inflammation can facilitate the development of targeted and disease-modifying therapy. In particular, IgE autoantibodies against self-antigens are thought to be linked to the pathophysiology and course of chronic inflammatory diseases including atopic dermatitis, asthma, bullous pemphigoid, chronic spontaneous urticaria, and systemic lupus erythematosus. The European Network for IgE-Mediated Autoimmunity (ENIGMA) aims to unravel the role and relevance of IgE autoantibodies in chronic inflammatory diseases. In this review, the ENIGMA consortium presents the concept of IgE-dependent autoimmunity and autoallergy, summarizes current knowledge and its gaps, and focuses on ways to enhance our understanding of these complex processes.

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Key words : Atopic dermatitis, asthma, autoantibodies, autoimmune diseases, autoimmunity, bullous pemphigoid, chronic inflammatory skin diseases, chronic spontaneous urticaria, IgE, systemic lupus erythematosus

Abbreviations used : α-NAC, AA, AD, AR, BAT, BP, BTK, CID, CSR, CSU, dsDNA, ECP, ENIGMA, EPX, FABP, FLG, Kd, mAb, MC, MnSOD, SLE, SLEDAI, SPT, TF, TLO, TPO

Plan

IgE in allergy, autoimmunity, and autoallergy

Natural course

Predisposing factors

Understanding IgE autoimmunity and autoallergy

Animal models

Preclinical human models

Correlating IgE autoantibodies with clinical disease

IgE autoimmunity-targeted treatments

Conclusions

The first 3 authors contributed equally to this article, and all should be considered first author. The last 2 authors contributed equally to this article, and both should be considered senior author.

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Vol 157 - N° 1

P. 1-17 - janvier 2026 Retour au numéro

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Understanding IgE-mediated autoimmunity and autoallergy - 05/01/26

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