The neuromuscular junction (NMJ), the connection between nerve and muscle, is an essential anatomic site that warrants careful consideration. Dysfunction at this junction often leads to skeletal muscle weakness with a multitude of clinical manifestations. Disorders of the NMJ primarily encompass myasthenia gravis, Lambert-Eaton syndrome, botulism, and organophosphate poisoning. This article will review diseases and disorders of the NMJ, their clinical presentations, and approach to management.