The nitric oxide donor pentaerythritol tetranitrate lowers hypertension and angiogenic imbalance in pregnancies with impaired uterine perfusion—a secondary analysis of a randomized trial - 02/02/26
Doi : 10.1016/j.ajog.2025.10.006
Thomas Lehmann, PhD
Institute of Medical Statistics and Computer Science, Jena University Hospital, Jena, Germany
Center for Clinical Studies, Jena University Hospital, Jena, Germany
Matej Komar, MD, Jennifer Lucia Winkler, MD
Department of Gynecology and Obstetrics, Dresden University of Technology, Dresden, Germany
Mateja Condic, MD, Brigitte Strizek, MD
Department of Obstetrics and Prenatal Medicine, University Hospital Bonn, Bonn, Germany
Sven Seeger, MD, Yvonne Jäger, MD
Department of Gynecology and Obstetrics, Perinatal Center, St Elisabeth and St Barbara Halle, Halle (Saale), Germany
Ulrich Pecks, MD, Christel Eckmann-Scholz, MD
Department of Obstetrics, Christian-Albrechts-University of Kiel, Kiel, Germany
Karl Oliver Kagan, MD, Markus Hoopmann, MD
Department of Feto-Maternal Medicine, Women’s University Hospital Tübingen, Tübingen, Germany
Constantin S. von Kaisenberg, MD, Lars Brodowski, MD
Department of Obstetrics, Gynecology and Reproductive Medicine, Hannover Medical School, Hannover, Germany
Anne Tauscher, MD, Susanne Schrey-Petersen, MD
Department of Obstetrics and Gynecology, University of Leipzig, Leipzig, Germany
Ulrike Friebe-Hoffmann, MD, Krisztian Lato, MD
Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany
Christoph Hübener, MD, Maria Delius, MD
Department of Obstetrics and Gynecology, Perinatal Center, University Hospital, Campus Grosshadern, Ludwig Maximilian University of Munich, Munich, Germany
Stefan Verlohren, MD, Dorota Sroka, MD
Department of Obstetrics, Charité – University Medicine Berlin, Berlin, Germany
Dietmar Schlembach, MD
Vivantes Network of Health GmbH, Clinicum Neukoelln, Clinic for Obstetric Medicine, Berlin, Germany
Laura de Vries, MD, Katrina Kraft, MD
Department of Obstetrics and Gynecology, Städtisches Klinikum Harlaching, Munich, Germany
Gregor Seliger, MD
Center for Reproductive Medicine and Andrology, University Medical Center Halle (Saale), Halle (Saale), Germany
Ekkehard Schleußner, MD
On behalf of the
On behalf of the
PETN study group
Department of Obstetrics, Jena University Hospital, Jena, Germany
Video |
(6.93 Mo)
Plan
| Current affiliations: Department of Obstetrics, University of Cologne, Medical Faculty and University Hospital Cologne, Cologne, Germany (Dr Groten); Department of Obstetrics and Gynecology, AND Institute of Midwifery, University Hospital of Würzburg, Würzburg, Germany (Dr Pecks); Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Dr Verlohren). |
|
| The authors report no conflict of interest. |
|
| Funding for this trial was provided by the German research foundation to T.G. (GR1955/4-1). The funding organization is a public institution and had no role in the design and conduct of the study; collection, management, and analysis of the data; or preparation, review, approval of the manuscript and decision to submit the manuscript for publication. |
|
| The trial was registered at Deutsches Register Klinischer Studien (DRKS) (DRKS00011374) on June 27, 2017, ( navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00011374 ) and ClinicaltTials.gov (NCT03669185) ( NCT03669185 ) on the September 14, 2018, with the clinical trial identification number EudraCT (2016-004396-51). The date of initial participation enrolment was the August 15, 2017. |
|
| The data set will be available to appropriate academic parties on request from the Chief Investigator, Tanja Groten, in accordance with the data sharing policies of the Jena University Hospital and the German research foundation. Input from the co-investigator group will be evaluated when applicable. The study protocol is available at PMC6744635 . |
© 2025
The Author(s). Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 234 - N° 2
P. e28-e36 - février 2026 Retour au numéro
Article précédent
- Supplement use and weight loss for polycystic ovary syndrome: how much weight should we give the information we see on TikTok?
- Rose Darcy, Alison Almgren-Bell, Jessica Almgren-Bell, Sarah Capelouto Cromack, Christina E. Boots, Mary Ellen Pavone
- Association between germline BRCA1 pathogenic variants and uterine serous carcinoma among women with breast cancer: a population-based analysis
- Roni Nitecki Wilke, Nuria Agusti, Nuria Agusti, Chi-Fang Wu, Maria D. Iniesta, William B. Manning, David Viveros-Carreno, Allison W. Kurian, J. Alejandro Rauh-Hain, Alexander Melamed
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?