Oral medicine is the dental specialty dedicated to the oral health care of medically complex patients and the diagnosis and management of medically related diseases, disorders, and conditions affecting the oral and maxillofacial region. Like other dental and medical specialties, oral medicine patient care is often impacted by challenges such as limited manpower, time, or resources. Artificial intelligence (AI) tools seek to supersede these challenges by automating human tasks and ushering greater efficiency and productivity. For direct patient care in oral medicine, AI has applications in risk prediction modeling, diagnosis establishment, treatment decision-making, and prognosis and outcomes prediction modeling.