Artificial intelligence (AI) is an exciting technology that has the potential to transform endodontics. Recent advances include the application of AI to improve the detection and classification of anatomic structures and of endodontic disease, such as periapical lesions and fractures. AI applications will help clinicians with decision-making, treatment support, and real-time guidance. There are improvements to be made and challenges to be overcome before its mainstream adaptation in dentistry, including the black-box phenomenon, domain shift, or data harvest from medical chart records. This review addresses the potential and the concerns regarding AI implementation from the perspective of the practicing dentist.