Opportunistic thoracic CT scan over bone densitometry in CF care: Is it possible to screen for osteoporosis using a CT scan? - 12/03/26
, Marcelo Tadday Rodrigues a, Gabriele Carra Forte a, Rubens Gabriel Andrade Feijó a, Rodrigo Abensur Athanazio b, Bruno Hochhegger a, c, Leonardo Araújo Pinto aAbstract |
Introduction |
Cystic fibrosis (CF) is an autosomal recessive disease that alters ionic transport in the body's secretions, including those of the lung mucosa, and is the most common hereditary respiratory disease in the Western world. One of the causes of morbidity and decreased quality of life in patients with CF is osteoporosis, which is currently assessed by bone densitometry.
Methods |
bi-centric, cross-sectional, retrospective study, reviewing data contained in the medical records of patients with cystic fibrosis participants who were treated at 2 CF reference centers, and reanalysis of chest tomography scans performed annually during checkup, in comparison with their bone densitometry measurements from the same period.
Results |
A total of 73 CF patients were evaluated. Patients with DXA-defined osteoporosis showed significantly lower HU values. Using 215HU as the cutoff, we obtained 83% sensitivity and 68% specificity for osteoporosis. Area under the ROC curve was 0.86 using analyses of T10 to T12 vertebrae.
Conclusions |
Chest computed tomography may serve as an opportunistic screening for identifying patients with cystic fibrosis at increased risk of low bone mineral density, particularly when CT examinations are already being performed for other clinical reasons.
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| ☆ | Take Home Message: Thoracic CT scan may be an alternative to DXA for screening for osteoporosis in CF patients, reducing time spent and the financial burden in CF patient care. |
Vol 254
Article 108739- avril 2026 Retour au numéro
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