Image interpretation represents a critical component of emergency medicine practice, as diagnostic accuracy directly informs clinical management, treatment decisions, and patient disposition. Errors in radiographic interpretation arise from a variety of sources; however, cognitive biases are responsible for approximately 74% of misinterpretations and are strongly associated with adverse patient outcomes. This article highlights three particularly prevalent cognitive biases—satisfaction of search, anchoring, and normalization bias—and illustrates their impact through clinical vignettes. In addition, strategies for bias recognition and mitigation are presented to support diagnostic accuracy and enhance patient safety in the emergency department.