Investigating optimal warming techniques for hypothermia in a swine model of ischemia - 10/04/26
, Brooklyn Williams a, Grace Pak a, Bobby Zhang a, Beau Prey a, Andrew Francis a, James Williams a, Luke Pumiglia a, Erik Roedel a, Mike Lallemand a, John McClellan a, Nicholas Ieronimakis b, Jason Bingham aAbstract |
Introduction |
With trauma, hypothermia is associated with increased bleeding and worse outcomes yet the pace of rewarming is unproven and its influence unclear. We hypothesized that the rate of rewarming influences outcomes and evaluated its impact in a porcine model of trauma.
Methods |
Pigs underwent controlled hemorrhage and hypothermia to 32 °C for 1 h, followed by rapid or slow rewarming for 3 h. Hemodynamics and coagulation were compared along with liver gene expression.
Results |
The mean temperature reached between fast (37.9±0.13 °C) and slow groups (34.5±1.2 °C) was significantly different (p < 0.01). The slow group had a lower heart rate and the mean arterial pressure (MAP) was lower with both slow and fast. No major differences in lactate, pH, coagulation or gene expression were observed.
Conclusion |
Our study supports rapid rewarming for reversing hypothermia post hemorrhage. Further research is needed to evaluate long-term outcomes within clinical settings.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Rapid rewarming reversed trauma-induced hypothermia in a large animal hemorrhage model. |
• | Slow vs rapid rewarming produced similar coagulation and metabolic responses after trauma. |
• | Rewarming rate did not change inflammatory gene expression in hypothermic hemorrhage. |
• | Hypothermia caused hemodynamic decline, but rewarming strategy did not worsen physiology. |
• | Findings support rapid rewarming as a safe approach for treating hypothermia after bleeding. |
Keywords : Hypothermia, Hemorrhage, Trauma, Coagulation, Porcine model, Swine model, Rewarming
Plan
| This article is part of a special issue entitled: NPSA 2026 published in The American Journal of Surgery. |
Vol 256
Article 116912- juin 2026 Retour au numéro
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