Antibiotic tolerance and safety in infective endocarditis: A focus on older patients - 01/05/26
, Marion PÉPIN a, gon behalf of the endocarditis team of A. Paré Hospital
Highlights |
• | One quarter of older adults with infective endocarditis experience antibiotic-related adverse events. |
• | Age and functional autonomy were not associated with antibiotic intolerance. |
• | Cognitive impairment was independently associated with adverse events. |
• | Streptococcal infective endocarditis was associated with fewer adverse events. |
• | Multidisciplinary endocarditis team management is conducive to safer, more individualized care. |
Abstract |
Background |
Infective endocarditis (IE) is a rare but severe disease with high morbidity and mortality, increasingly affecting older adults. Data on antibiotic tolerance in this population remain limited.
Methods |
We conducted a hospital network cohort study including all patients over 65 years old. diagnosed with IE between May 2016 and August 2024 in the greater Paris area. Antibiotic-related adverse events (AEs) were systematically collected, within six months of follow-up.
Results |
Among 83 patients (median age: 84 years), 21 (25.3%) experienced at least one AE. Patients with AEs had longer hospital stays but similar age, autonomy, and in-hospital outcomes compared to those without AEs. Cognitive impairment was significantly associated with a higher risk of AEs, particularly in patients aged ≥ 75 years. Streptococcal IE was less frequently associated with AEs. Most AEs were biological abnormalities or clinical events, mainly involving amoxicillin and cefazolin.
Conclusions |
Age alone did not markedly affect antibiotic tolerance.
Le texte complet de cet article est disponible en PDF.Keywords : Infective endocarditis, Older adults, Adverse drug events, Cognitive impairment, Multidisciplinary care
Plan
Vol 56 - N° 3
Article 105258- avril 2026 Retour au numéro
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