Practical Recommendations for Harmonization of Hemostasis Testing Across Hospital Sites - 15/05/26

Doi : 10.1016/j.cll.2026.02.008

Emmanuel J. Favaloro, PhD, FFSc (RCPA) ^a,^b,^c,^⁎ , Leonardo Pasalic, FRCPA, FRACP, PhD ^a,^d

^a Department of Haematology, Sydney Centres for Thrombosis and Haemostasis, Institute of Clinical Pathology and Medical Research (ICPMR) and Research and Education Network (REN), Westmead Hospital, Westmead, New South Wales, Australia

^b School of Dentistry and Medical Sciences, Faculty of Science and Health, Charles Sturt University, Wagga Wagga, New South Wales, Australia

^c School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Westmead Hospital, Westmead, New South Wales, Australia

^d Westmead Clinical School, University of Sydney, Westmead, New South Wales, Australia

^∗ Corresponding author. Department of Haematology, Sydney Centres for Thrombosis and Haemostasis, Institute of Clinical Pathology and Medical Research (ICPMR) and Research and Education Network (REN), Westmead Hospital, Westmead, New South Wales, 2145, Australia. Department of Haematology Sydney Centres for Thrombosis and Haemostasis Institute of Clinical Pathology and Medical Research (ICPMR) and Research and Education Network (REN) Westmead Hospital Westmead New South Wales 2145 Australia

Résumé

Harmonization of hemostasis testing can be achieved in any laboratory network, including a mix of different instruments and assays. This process requires engagement with key stakeholders. The group should identify ideal streamlined total testing processes for different tests and laboratories. The processing of high volume/simple automated tests can be improved by an expert-rules set that can autoverify certain test results, and well as reflexing to other tests to improve their diagnostic value. Low volume tests can be harmonized to improve testing efficiency and utility. This review provides pointers to achieving workable harmonization across a variety of laboratories and hemostasis tests.

Le texte complet de cet article est disponible en PDF.

Keywords : Harmonization, Standardization, Hemostasis testing, Laboratory network, Auto-verification

Plan

Key points

Introduction

A Short History of Our Evolving Laboratory Networks

A Short History of Harmonization of Hemostasis Testing Within Our Evolving Laboratory Networks

A roadmap (with recommendations) to assist harmonization of hemostasis assays in other laboratory networks

Harmonization of International Normalized Ratio Testing

Harmonization of Routine Coagulation Testing, Including Autoverification and Reflex Testing

Harmonization of Specialized Hemostasis Testing

Discussion

Summary

Clinics care points

Export

Vol 46 - N° 2

P. 327-350 - juin 2026 Retour au numéro

Article précédent

The Role of Hypoxia in Vascular Endothelial Dysfunction and Venous Thromboembolism
Angelo Ascani, John-Bjarne Hansen, Omri Snir

| Article suivant

Viscoelastic Testing for the Laboratorian : Recent Advances and Practical Advice
Oksana Volod

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

connectez-vous ou créez un compte

Practical Recommendations for Harmonization of Hemostasis Testing Across Hospital Sites - 15/05/26

Résumé

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL