Antibiotic Considerations in the Critically Ill : Empiric Choices and Dosing - 22/05/26

Résumé |
Treating infections in critically ill patients is uniquely challenging because of diverse disease states, high rates of antimicrobial resistance, pharmacokinetic changes, and a high risk of mortality that leaves little margin for error. Optimal management requires balancing early, appropriate antimicrobial therapy with risks of toxicity and resistance. To do so, clinicians must integrate microbiologic diagnostics, pathogen epidemiology, patient-specific risk factors, and local resistance rates with an understanding of antimicrobial agents’ spectrum and pharmacologic properties and patients’ altered pharmacokinetics and pharmacodynamics.
Le texte complet de cet article est disponible en PDF.Keywords : Critical illness, Antibacterial agents, Pharmacokinetics, Drug resistance, Multiple, Bacterial, Sepsis, Drug therapy
Plan
Vol 42 - N° 3
P. 585-609 - juillet 2026 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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