A Cloud Enabled Hybrid CNN Transformer Framework with Attention Mechanisms for Scalable Alzheimer’s Disease Staging from Structural MRI - 09/06/26
, D. Prabha Devi 2
, A. Kodieswari 3
, Arfat Ahmad Khan 4
, V. Suma 1
, Shahid Kamal 5, ⁎
, Fasee Ullah 6 
Abstract |
Alzheimer's disease (AD) is a neurodegenerative condition that causes cognitive impairment and structural brain changes, and early diagnosis is crucial for treatment. This paper proposes a cloud-based hybrid deep learning architecture for scalable Alzheimer's disease staging based on structural magnetic resonance imaging (MRI). The hybrid architecture leverages convolutional neural networks (CNNs), attention, and Transformer-based modeling to capture both local and global spatial features in MRI images. CNN extracts multi-dimensional features, while the attention and Transformer layers enrich context representation for more accurate staging of the disease. The framework was trained on a GPU-enabled computer using the PyTorch deep learning framework on a publicly available MRI dataset for Alzheimer's disease from the Kaggle website. The model was cross-validated on the OASIS dataset to assess its generalizability. The experimental findings showed that the proposed approach achieved an accuracy of 99.65% on the Kaggle dataset, which is better than several state-of-the-art deep learning models such as VGG16, ResNet variants, DenseNet121, EfficientNet-B0, and Vision Transformer. This approach also achieved an accuracy of 91.67% on the OASIS dataset, demonstrating the model's ability to generalize across neuroimaging datasets. To enable practical usage and accessibility, the trained model was also deployed in a cloud-based inference environment on Hugging Face Spaces, which allows MRI image upload and prediction from a web browser. The scalable and cloud-deployable design allows scalable medical image processing and integration with cloud-based diagnostic systems as well as telemedicine-based healthcare solutions. These findings demonstrate the potential for robust and accessible staging of Alzheimer's disease using the proposed framework in clinical settings.
Le texte complet de cet article est disponible en PDF.Keywords : Alzheimer’s disease, Structural MRI, Grad-CAM explainability, Hybrid CNN–Transformer, Attention mechanism, Deep learning, Multi-class classification
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