Background: Tribulus terrestris L. ( Gokshura ) is a widely used medicinal plant across traditional systems and commercialised as a dietary supplement. Regulatory attention has been noted regarding safety concerns, particularly at higher doses and concentrated formulations across the globe.

Objectives: To map global scientific evidence on the safety of Tribulus terrestris L., identify research trends and collaborations, and highlight gaps in clinical safety evaluation.

Methods: A bibliometric review was conducted to understand the trend in research, particularly on the toxicological domain of Tribulus terrestris L. by analysing the metadata of published literature from Scopus and the Medline database from 1978 to 2025. Data search and cleaning were the preliminary steps followed by analysis using software tools such as VOS viewer and Biblyoshiny to evaluate publication growth, influential journals, authors, institutions, countries, collaboration networks, co-citation patterns, and keyword co-occurrence.

Results: India emerged as the leading contributor, accounting for half of the publications and citations, followed by China and Iran. Research output was disseminated across 232 sources, with the Journal of Ethnopharmacology identified as the most impactful journal. Keyword and co-citation analyses demonstrated that the literature is predominantly focused on preclinical toxicology, emphasising acute toxicity, histopathology, and hepatic and renal biomarkers, while clinical safety studies and post-marketing surveillance remain limited. Skewed distribution of authorship was noted, indicating episodic research engagement rather than a sustained long-term programme.

Conclusion: The findings from the bibliometric analysis highlight a critical gap in clinical toxicology and long-term safety evaluation. By systematically mapping the evolution, this study provides an evidence-based framework to guide future investigations and support regulatory decisions.