The unique preparation of occupational therapists enables them to strongly influence an individual with upper limb absence. Understanding the phases of prosthetic rehabilitation with patient-centered protocols is required to meet the functional needs of individuals fit with diverse prostheses, including presurgery and postsurgery, preprosthetic fitting, and prosthetic training interventions to facilitate optimal functional outcomes. These protocols support independence and are adapted dependent on the individual client factors and the prosthetic device used. A collaborative interprofessional dynamic that engages the team is crucial to prepare each patient to reach their maximum potential and to enjoy wellness, well-being, and quality of life.