Seroprevalence of hepatitis E virus infection among pregnant women in South Africa at time of delivery - 26/08/26
, Shabir A. Madhi a, c, 1, Gaurav Kwatra a, b, d, e, 1Abstract |
Background |
Hepatitis E virus (HEV) infection in late pregnancy is associated with adverse maternal and pregnancy outcomes. We evaluated HEV infection at delivery among South African women with and without human immunodeficiency virus (HIV) infection.
Methods |
Archived maternal serum samples collected at delivery from 333 South African women with and without HIV (147 term births, 130 preterm births, and 56 stillbirths) were tested for HEV-specific immunoglobulin M (IgM) and immunoglobulin G (IgG).
Results |
Acute HEV infection (IgM-positive) was detected in two women [0.6% (95% CI: 0.15%–2.38%; 2/333)], both of whom were living with HIV. HEV IgG seropositivity was found in 2.4% (95% CI: 1.20%–4.74%; 8/333), including 3.55% (95% CI: 1.48%–8.26%; 5/141) of women with HIV and 1.57% (95% CI: 0.50%–4.77%; 3/191) without HIV infection. HEV sero-positivity did not differ with regard to pregnancy outcomes.
Conclusion |
Among South African women, prevalence at delivery of acute or past HEV infection was low.
Le texte complet de cet article est disponible en PDF.Highlights |
• | In a South African cohort, prevalence of acute HEV infection in pregnant women at the time of delivery was low. |
Keywords : Hepatitis E virus, Infection, Seroprevalence, Antibodies, Pregnant women
Plan
Vol 56 - N° 6
Article 105336- août 2026 Retour au numéro
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- Cerebrospinal fluid IgM cross-reactivity among arboviruses in Japanese encephalitis patients from southern India
- Amrita Pattanaik, D. Swapna Reddy, Chiranjay Mukhopadhyay
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