Associations Between Routine Vaccinations and the Risk of New-Onset Idiopathic Uveitis - 01/09/26
Highlights |
• | Vaccinated patients have lower risk of new-onset idiopathic uveitis. |
• | The varicella vaccine provided the highest risk reduction of tested vaccines. |
• | Anterior uveitis was the predominant risk-reduced subtype of new-onset uveitis. |
• | Vaccines may confer an immunologic profile protective against ocular inflammation. |
Résumé |
Objective |
To evaluate the association between vaccination and the risk of new-onset idiopathic uveitis (NIU).
Design |
Retrospective cohort study of aggregated electronic health records from multiple health systems across the United States.
Subjects |
Subjects who received the coronavirus disease 2019 (COVID-19), human papillomavirus (HPV), varicella, recombinant herpes zoster, or live herpes zoster vaccinations from 2006 to 2025 and propensity-score matched controls.
Intervention |
Vaccines against COVID-19, HPV, varicella, recombinant herpes zoster, or live herpes zoster.
Main Outcomes and Measures |
The main outcome was the incidence of NIU at 3, 6, and 12 months following vaccination. Vaccinated patients were compared with matched controls who did not receive the respective vaccines. Analyses were repeated, excluding patients with previous diagnosis of the respective viral infection. Risk ratios (RR) with 95% confidence intervals (CIs) were calculated for overall NIU and constituent subtypes (anterior, intermediate, posterior, and panuveitis).
Results |
All tested vaccinations were associated with reduced risk of NIU through 12 months compared with matched controls. Relative risk reductions were 65% for COVID-19 (RR, 0.35; CI, 0.33-0.37), 56% for HPV (RR, 0.44; CI, 0.35-0.54), 71% for varicella (RR, 0.29; CI, 0.25-0.33), 68% for live zoster (RR, 0.32; CI, 0.23-0.43), and 69% for recombinant zoster vaccination (RR, 0.31; CI, 0.26-0.37). Similar reductions were observed after excluding patients with prior diagnoses of the respective viral infections.
Conclusions |
Vaccination was associated with a lower risk of idiopathic uveitis, representing the complex interplay between immune modulation and the development of NIU.
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Vol 290
P. 204-213 - octobre 2026 Retour au numéro
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