Sex differences in the association between triglyceride glucose frailty index and cancer risk: A nationwide prospective cohort study - 19/09/26
Summary |
Objective |
Triglyceride glucose frailty index (TyG-FI) has been proposed as a novel biomarker for insulin resistance and physiological decline. However, the association between TyG-FI and the risk of cancer, particularly regarding sex difference, remains unclear.
Methods |
A total of 7914 middle-aged and elderly participants were enrolled from the China Health and Retirement Longitudinal Study (CHARLS). The Cox proportional hazard models and restricted cubic spline analysis were applied to explore the association between TyG-FI and the risk of cancer.
Results |
During a median follow-up of 9 years, 244 (104 events in men, 140 events in women) participants had occurred cancer. Our findings revealed a significant positive linear association between TyG-FI and the occurrence of cancer. Cox regression analysis revealed that elevated TyG-FI levels were associated with higher cancer risk (HR: 1.22, 95% CI: 1.06, 1.39). The association was still significant in women (HR: 1.42, 95% CI: 1.21, 1.66), but not in men (HR: 0.87, 95% CI: 0.65, 1.15).
Conclusions |
Our findings revealed that elevated TyG-FI levels were associated with higher cancer risk. TyG-FI was an independent prognostic predictor for the risk of cancer in women, but not in men.
Le texte complet de cet article est disponible en PDF.Keywords : Triglyceride glucose, Frailty index, Cancer, Sex, CHARLS
Plan
Vol 113 - N° 10
janvier 2026 Retour au numéro
Article précédent
- Quand les modèles butent sur le réel : l’intelligence artificielle dans la pratique clinique de l’oncologie
- Sylvain Garciaz, Alexandre de Nonneville, Dominique Maraninchi
- Oncologie de précision en milieu libéral : spécificités et perspectives de l'activité d’oncogénétique et de la RCP moléculaire
- Daniel Toledano, Benoist Chibaudel, Jean-Marc Costa, Hanene Boudabous, Marie-Magdelaine Coude, Armelle Luscan, Anne Legrand, Etienne Muller, Nicolas Philippe, Aurélie Driss Corbin, Paul Ihout, Pierre Squara, Hanah Lamallem, Emile Dinet, Pascal Pujol, Alain Toledano
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?