Universal single-step warming of vitrified blastocysts: feasibility across two commercial kits and comparison with the conventional warming procedure - 25/10/26
, Gabor Vajta c, d, Da Li a, ⁎ Abstract |
Conventional vitrification systems for human gametes and embryos typically necessitate brand-specific warming solutions. This retrospective longitudinal cohort study on 2,563 vitrified/warmed blastocysts investigates the efficacy of a universal single-step warming (USSW) protocol for human blastocysts vitrified using distinct commercial systems, combining vitrification and warming kits from two manufacturers: Kitazato (Japan) and VitaVitro Biotech (China) according two different warming protocols: the conventional protocol (UW) or with the single-step warming (USSW). Cryo-survival was 100% across all groups. Clinical and ongoing pregnancy, miscarriage, and live birth rates were comparable among groups. Implantation rate differed overall (p = 0.03), but no pairwise differences remained significant after Bonferroni correction. This study provides preliminary evidence suggesting that the universal single-step warming (USSW) protocol may simplify kit interchangeability and shorten the warming procedure.
Le texte complet de cet article est disponible en PDF.Keywords : Universal warming, Vitrification, Warming, Non-permeating solutes, Single-step warming
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Vol 55 - N° 10
Article 103304- décembre 2026 Retour au numéro
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