P02-100 - QEEG cordance in the prediction of response to ketamine in depressive patients - interim analysis of randomized controlled trial - 05/05/11
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Résumé |
Objective |
Rapid and robust antidepressant-like effect of ketamine in subanesthetic doses was already manifested in depressive patients. Maximum of mood improvement was shown within the period from 2 hours to 3 days. Previous studies proved predictive value of prefrontal QEEG theta cordance reduction after 1 week on a new antidepressant.
Congruently with previous findings we hypothesised in our compressed model decrease of QEEG cordance in 10 minutes of ketamine hydrochloride infusion as the prediction of antidepressant response.
Methods |
14 MDD patients (6F/8M) diagnosed with a moderate to severe depressive episode without psychotic symptoms were included. All of the participants received the 30minutes lasting only infusion with subanesthetic dose of ketamine hydrochloride solution (0.54mg/kg). EEG measurements on the baseline, after 10 and 30minutes of infusion were taken into account in computation of QEEG cordance.
Results |
9 (64.3%) of subjects responded to single ketamine infusion following day and 8 (88.9%) of them decreased QEEG cordance. T-test pair comparison found significant difference between baseline and after 10 minutes of ketamine infusion in responders (F=4.12; p<0.003).
Conclusions |
Preliminary results have shown the tendency of prefrontal QEEG cordance to decrease as a ketamine response prediction. Larger sample size is needed to increased precision in estimates of cordance sensitivity and specificity. Combination of latest QEEG method and fastest-acting antidepressant-like effect of ketamine in this trail is unexampled. Supported by IGA (MH CR) No.NS10379-3, 1M0517 (MEYS CR), MZ0PCP2005 (MH CR). Local Ethics Committee approval has been granted.
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Vol 26 - N° S1
P. 695-696 - 2011 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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