Minimal (clinically) important differences for the Fatigue Assessment Scale in sarcoidosis - 28/07/11
, Petal A.H.M. Wijnen b, d, Marjolein Drent b, e
Corresponding author. CoRPS, Department of Medical Psychology, Room P510, Tilburg University, Warandelaan 2, PO Box 90153, 5000 LE Tilburg, The Netherlands. Tel.: +31 13 4662175; fax: +31 13 4662067.Summary |
Objective |
The usefulness of any questionnaire in clinical management and research trials depends on its ability to indicate a likelihood of treatment success during follow-up. The Minimal Clinically Important Difference (MCID) reflects a clinically relevant change score. The aim of this study was to estimate the MCID for the Fatigue Assessment Scale (FAS) in patients with sarcoidosis.
Methods |
Outpatients (n = 321) of the ild care team of the Department of Respiratory Medicine of the Maastricht University Medical Centre, The Netherlands, participated in this prospective follow-up study. Anchor-based and distribution-based methods were used to estimate the MCID. Based on the anchor Physical Quality of Life, a Receiver Operating Characteristic (ROC) was obtained. The distribution-based methods consisted of the Effect Size and Standard Error Measurement (SEM).
Results |
The anchor-based MCID found with ROC was 3.5. The distribution-based methods showed that the corresponding change scores in the FAS for a small effect was 4.2. The SEM criterion was 3.6 points change in the FAS.
Conclusions |
Based on the anchor-based and distribution-based methods, the MCID is a 4-point difference on the FAS. This MCID can be used in the follow-up of fatigue (FAS) in clinical trials and in the management of individual sarcoidosis cases.
Le texte complet de cet article est disponible en PDF.Keywords : Sarcoidosis, Minimal clinically important difference, Fatigue, Fatigue Assessment Scale
Plan
Vol 105 - N° 9
P. 1388-1395 - septembre 2011 Retour au numéro
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