Impaired Glucose Absorption in Children with Severe Malnutrition - 02/08/11
, Martijn N. Spoelstra, MSc c, Andrea Mari, PhD e, Marijke Mendel, MSc c, Patrick F. van Rheenen, MD, PhD d, Edward Senga, MSc a, Theo van Dijk, PhD c, Geert Tom Heikens, MD, PhD b
Reprint requests: Robert Bandsma, MD, PhD, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8.Abstract |
Objective |
To quantify intestinal glucose absorption in children with two types of severe malnutrition, kwashiorkor and marasmus, compared with healthy children.
Study design |
Children with kwashiorkor (n = 6) and marasmus (n = 9) and control subjects (n = 3) received a primed (13 mg/kg), constant infusion (0.15 mg/kg/min) of [6,6H2]glucose for 4.5 hours. Two hours after start of the infusion an oral bolus of glucose 1.75 g/kg labeled with [U-13C]glucose 10 mg/g was given and was followed by periodic blood sampling. Mathematical modeling was applied to determine oral glucose absorption.
Results |
Median total glucose absorption was 5.9 mmol/kg, interquartile range (IQR) 4.5-6.7 mmol/kg and 4.4 (IQR 2.9-5.9) mmol/kg in children with kwashiorkor and marasmus compared with 7.7 (IQR 5.8-9.0) mmol/kg in control subjects; P = .03 compared with marasmus). Children with the lowest glucose absorption were found specifically in the kwashiorkor group and marasmic children with hypoalbuminemia. Severe impairment in absorption correlated with urinary 8-hydroxydeoxyguanosine secretion (r = -0.62, P = .01).
Conclusions |
Severe malnutrition is associated with an impaired glucose absorption and decreased glucose absorption correlates with oxidative stress in these children.
Le texte complet de cet article est disponible en PDF.Mots-clés : 8-OHdG, HIV, IQR, RUTF, TTR, WHO
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| Supported through an International Fellowship Grant from the Nutricia Research Foundation (R.B.). The authors declare no conflicts of interest. |
Vol 158 - N° 2
P. 282 - février 2011 Retour au numéro
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