TNF-⍺ Gene Polymorphisms and Excessive Daytime Sleepiness in Pediatric Obstructive Sleep Apnea - 02/08/11
Reprint requests: Dr David Gozal, Department of Pediatrics, Comer Children’s Hospital, The University of Chicago, 5721 S Maryland Avenue, MC 8000, Suite K-160, Chicago, IL 60637.Abstract |
Objective |
To assess sleepiness, TNF-⍺ plasma levels, and genomic variance in the TNF-⍺ gene in children with obstructive sleep apnea (OSA).
Study design |
Children being evaluated for OSA (n = 60) and matched control children (n = 80) were assessed with a modified Epworth Sleepiness Scale questionnaire and underwent a blood draw the morning after nocturnal polysomnography. TNF-⍺ plasma concentrations were assayed using ELISA, and genomic DNA was extracted. Genotyping and allelic frequencies were determined for 4 TNF-⍺ single nucleotide polymorphisms using real-time polymerase chain reaction genotyping assays.
Results |
Morning TNF-⍺ levels and Epworth Sleepiness Scale scores were increased in the presence of OSA, but substantial variability was present. Although TNF-⍺ plasma concentrations were globally increased in OSA, most of the variance was attributable to the presence or absence of TNF-⍺ -308G gene polymorphism.
Conclusions |
TNF-⍺ levels are increased in a subset of children with OSA, particularly among those harboring the TNF-⍺ -308G single nucleotide polymorphism. Among the latter, significant increases in excessive daytime sleepiness symptoms are also present. The relatively high variability of excessive daytime sleepiness in pediatric OSA may be related to underlying TNF-⍺ gene polymorphisms, particularly -308G.
Le texte complet de cet article est disponible en PDF.Mots-clés : A, AHI, BMI, ESS, G, OSA, TNF, TST
Plan
| Supported by the National Institutes of Health (grant HL-65270 to D.G.). The authors declare no conflicts of interest. |
Vol 158 - N° 1
P. 77-82 - janvier 2011 Retour au numéro
Article précédent
- Effects of an Exercise Program in Children with Cystic Fibrosis: Are There Differences between Females and Males?
- Wolfgang Gruber, David M. Orenstein, Klaus Michael Braumann, Karl Paul, Gerd Hüls
- Long-Term Effects of Prenatal Omega-3 Fatty Acid Intake on Visual Function in School-Age Children
- Caroline Jacques, Emile Levy, Gina Muckle, Sandra W. Jacobson, Célyne Bastien, Éric Dewailly, Pierre Ayotte, Joseph L. Jacobson, Dave Saint-Amour
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?