Predictive factors for indeterminate result on the QuantiFERON test in an intermediate tuberculosis-burden country - 02/08/11
Corresponding author. Tel.: +82 2 2228 1946; fax: +82 2 393 6884.Summary |
Objectives |
The QuantiFERON-TB Gold In-Tube (QFT-G IT) test is based on the cellular immune response, and this assay can result in indeterminate results for the diagnosis of tuberculosis. The occurrence of indeterminate results may decrease the clinical usefulness of this test. Therefore, we investigated possible predictive factors that can influence the occurrence of indeterminate results from the QFT-G IT test.
Methods |
We conducted a case-control study with 162 case patients who had indeterminate results from a QFT-G IT test at a tertiary hospital in South Korea, from September 2006 to September 2009.
Results |
Of the 1276 patients, 162 (12.7%) cases that underwent QFT-G IT testing were reported as indeterminate results. Severe lymphopenia (odds ratio [OR] = 8.839; p < 0.001), chronic renal disease (OR = 2.838; p = 0.007), autoimmune disease (OR = 2.527; p = 0.017) and chronic lung disease (OR = 3.169; p = 0.007) were independent predictive factors for indeterminate results from a QFT-G IT test.
Conclusion |
The patients with lower lymphocyte counts or immunosuppressive conditions showed a higher probability of indeterminate results from the QFT-G IT test. Careful attention to the pre-analytical conditions may be able to minimize this proportion.
Le texte complet de cet article est disponible en PDF.Keywords : Interferon-gamma release assays, QuantiFERON-TB Gold In-Tube test, Indeterminate results, Predictive factors
Plan
Vol 62 - N° 5
P. 347-354 - mai 2011 Retour au numéro
Article précédent
- Staphylococcus aureus bacteraemia – Nationwide assessment of treatment adequacy and outcome
- Hilmir Asgeirsson, Mar Kristjansson, Karl G. Kristinsson, Olafur Gudlaugsson
- Lack of association of tcdC type and binary toxin status with disease severity and outcome in toxigenic Clostridium difficile
- Simon D. Goldenberg, Gary L. French
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?