Genetic risks and childhood-onset asthma - 03/08/11
, Miriam Moffatt, DPhil a, David P. Strachan, MD b
Reprint requests: William Cookson, MD, DPhil, National Heart and Lung Institute, Imperial College, London SW3 6LY, United Kingdom.Abstract |
Recent large-scale genome-wide association studies have successfully identified several genetic loci that influence asthma susceptibility. The loci thus far identified confer a high population attributable risk for childhood-onset disease and have provided a better understanding of the primary mechanisms underlying asthma and a clear focus for new therapies to treat the disease. The loci are of limited utility for diagnostic or predictive genetic testing. This review considers different aspects of genetic risk, including individual, population, and familial risks, and explores how these different measures interact and how the next generation of genetic studies might be best designed.
Le texte complet de cet article est disponible en PDF.Key words : Asthma, childhood, genetic, familial, population, risk, genome-wide association
Abbreviations used : GWAS, OR, PARF, SNP
Plan
| Series editors: Joshua A. Boyce, MD, Fred Finkelman, MD, William T. Shearer, MD, PhD, and Donata Vercelli, MD |
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| Supported by the European Community Framework 6 Program and the Wellcome Trust. |
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| Terms in boldface and italics are defined in the glossary on page 267. |
Vol 128 - N° 2
P. 266-270 - août 2011 Retour au numéro
Article précédent
- Therapeutic strategies to reduce asthma exacerbations
- Genetic risks and childhood-onset asthma
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