Gene polymorphisms, breast-feeding, and development of food sensitization in early childhood - 03/08/11
, Guoying Wang, MD, PhD a, Xin Liu, MD, PhD a, Rajesh Kumar, MD, MS d, Hui-Ju Tsai, PhD a, c, Lester Arguelles, PhD a, Ke Hao, PhD e, Colleen Pearson, BA b, Kathryn Ortiz, BA b, Anthony Bonzagni, BA b, Stephanie Apollon, BA b, Lingling Fu, MS b, Deanna Caruso, MS a, Jacqueline A. Pongracic, MD d, Robert Schleimer, PhD f, Patrick G. Holt, DSc g, Howard Bauchner, MD b, Xiaobin Wang, MD, ScD a
Reprint requests: Xiumei Hong, MD, PhD, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, 2300 Children's Plaza, Box 157, Chicago, IL 60614.Abstract |
Background |
The effect of breast-feeding on the development of allergic disease is uncertain. There are no data that show whether this relationship varies by individual genotypes.
Objective |
We sought to evaluate the effect of breast-feeding and gene–breast-feeding interactions on food sensitization (FS) in a prospective US birth cohort.
Methods |
This study included 970 children who were prospectively followed since birth. Breast-feeding history was obtained from a standardized questionnaire interview. FS was defined as a specific IgE level of 0.35 kUA/L or greater to any of 8 common food allergens. Eighty-eight potentially functional single nucleotide polymorphisms (SNPs) were genotyped from 18 genes involved in innate immunity or TH1/TH2 balance. Logistic regression models were used to test the effects of breast-feeding and gene–breast-feeding interactions on FS, with adjustment for pertinent covariates.
Results |
Children who were ever breast-fed (n = 739), including exclusively breast-fed children, were at a 1.5 (95% CI, 1.1-2.1; P = .019) times higher risk of FS than never breast-fed children (n = 231). This association was significantly modified by rs425648 in the IL-12 receptor β1 gene (IL12RB1; P for interaction = .0007): breast-feeding increased the risk of FS (odds ratio, 2.0; 95% CI, 1.4-3.1; P = .0005) in children carrying the GG genotype but decreased the risk (odds ratio, 0.6; 95% CI, 0.3-1.4; P = .252) in children carrying the GT/TT genotype. Similar interactions were observed for SNPs in the Toll-like receptor 9 (TLR9; rs352140) and thymic stromal lymphopoietin (TSLP; rs3806933) genes. The interaction between the combined genotypes of the 3 SNPs and breast-feeding on FS was even stronger (P for interaction < 10−5).
Conclusion |
Our data suggest that the effect of breast-feeding on FS was modified by SNPs in the IL12RB1, TLR9, and TSLP genes both individually and jointly. Our findings underscore the importance of considering individual genetic variations in assessing this relationship.
Le texte complet de cet article est disponible en PDF.Key words : Breast-feeding, food sensitization, gene-environment interaction
Abbreviations used : AIM, CBIgE, FDR, FS, HWE, IL12RB1, LD, OR, SNP, TLR, TSLP
Plan
| The parent study was supported in part by March of Dimes PERI grants (20-FY02-56), the National Institute of Environmental Health Sciences (R21 ES011666), and the National Institute of Child Health and Development (R01 HD041702). The follow-up study was supported in part by the Food Allergy Initiative and the National Institute of Allergy and Infectious Diseases (NIAID; R21AI079872; U01AI090727) and the Department of Defense (W81XWH-10-1-0123). R. K. is supported by the National Heart, Lung, and Blood Institute (K23HL093023). X. L. and L. A. are supported by a career development award from the National Institutes of Health/Clinical and Translational Science Awards Program, Northwestern University (KL2RR025740). X. L. also is supported by the NIAID (R21AI087888). |
|
| Disclosure of potential conflict of interest: R. Kumar has received research support from the National Heart, Lung, and Blood Institute. The rest of the authors have declared that they have no conflict of interest. |
Vol 128 - N° 2
P. 374 - août 2011 Retour au numéro
Article précédent
- Anaphylaxis during anesthesia in France: An 8-year national survey
- Paul Michel Mertes, François Alla, Philippe Tréchot, Yves Auroy, Eric Jougla, Groupe d’Etudes des Réactions Anaphylactoïdes Peranesthésiques ∗
- Morbidity and mortality from ataxia-telangiectasia are associated with ATM genotype
- Romain Micol, Lilia Ben Slama, Felipe Suarez, Loïc Le Mignot, Julien Beauté, Nizar Mahlaoui, Catherine Dubois d’Enghien, Anthony Laugé, Janet Hall, Jérôme Couturier, Louis Vallée, Bruno Delobel, François Rivier, Karine Nguyen, Thierry Billette de Villemeur, Jean-Louis Stephan, Pierre Bordigoni, Yves Bertrand, Nathalie Aladjidi, Jean-Michel Pedespan, Caroline Thomas, Isabelle Pellier, Michel Koenig, Olivier Hermine, Capucine Picard, Despina Moshous, Bénédicte Neven, Fanny Lanternier, Stéphane Blanche, Marc Tardieu, Marianne Debré, Alain Fischer, Dominique Stoppa-Lyonnet, CEREDIH Network
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?