Afferent limb syndrome and delayed GI problems after pancreaticoduodenectomy for pancreatic cancer: single-center, 14-year experience - 04/08/11
Reprint requests: Richard A. Kozarek, MD, Virginia Mason Medical Center, 1100 9th Avenue, Seattle, WA 98101Résumé |
Background |
There are limited data on the incidence of afferent limb syndrome and other delayed GI problems in pancreatic cancer (PaC) patients, especially among long-term survivors (>2 years).
Objective |
To evaluate the incidence of afferent limb syndrome (chronic afferent limb obstruction resulting in pancreatobiliary obstruction) and delayed GI problems in PaC patients after pancreaticoduodenectomy (PD).
Design |
Retrospective case series.
Setting |
Tertiary referral center.
Patients |
PaC patients treated with PD (N = 186) over a 14-year period (January 1995-October 2009).
Interventions |
Endoscopic balloon dilation and stent placement, percutaneous biliary drainage.
Main Outcome Measurements |
Incidence of afferent limb syndrome and delayed GI complications (marginal ulcers, radiation enteropathy, anastomotic strictures).
Results |
Mean age was 63 ± 10 years; 55% of patients were male. Afferent limb syndrome was noted in 24 patients (13%). Median time to diagnosis was 1.2 years (range 0.03-12.3 years); obstruction was primarily caused by recurrent PaC (8 patients, 33%) and radiation enteropathy (9 patients, 38%). Afferent limb syndrome was more likely to develop in patients with 2 years or longer of follow-up (n = 71, [38%]) compared with patients with 2 years or less of follow-up, after controlling for age, sex, surgery type, and adjuvant treatment (adjusted odds ratio, 4.5; 95% CI, 1.8-11.7). Other delayed GI problems included radiation enteropathy (6%), marginal ulcers (5%), anastomotic strictures (4%), cholangitis/liver abscesses (5%), and GI bleeding (6%).
Limitations |
Retrospective, single-center study.
Conclusions |
GI problems, including afferent limb syndrome, are relatively common in PaC patients after surgery and adjuvant therapy. Clinicians should recognize and effectively treat these delayed GI problems, especially in long-term survivors.
Le texte complet de cet article est disponible en PDF.Abbreviations : PaC, PD, PTBD
Plan
| DISCLOSURE: The authors disclosed no financial relationships relevant to this publication. |
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| If you would like to chat with an author of this article, you may contact Dr Kozarek at Richard.Kozarek@vmmc.org. |
Vol 74 - N° 2
P. 295-302 - août 2011 Retour au numéro
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