Stupor and Fast Activity on Electroencephalography in a Child Treated With Valproate - 05/08/11
Doi : 10.1016/j.pediatrneurol.2009.02.003
Mario Mastrangelo, MD, Rosanna Mariani, MD, Alberto Spalice, MD, PhD, Valerio Rocchi, Paola Iannetti, MD ⁎ 
Pediatric Neurology Division, Department of Pediatrics, “La Sapienza” University of Rome, Rome, Italy
Communications should be addressed to: Dr. Iannetti; Department of Pediatrics; Child Neurology Division; “La Sapienza” University of Rome, Viale Regina Elena 324; 00161 Rome, Italy.Abstract |
The case of a 4-year-old girl with valproate-induced stupor and electroencephalographic pattern of increased fast activity is reported. Stupor and fast activity have been related to the effects on γ-aminobutyric acid type A (GABAA) receptors mediated by endozepines or by exogenous drugs such as benzodiazepines or barbiturates. The action of valproate in GABA metabolism and in GABA neuronal networks could produce a similar result through a hyperrecruitment of GABA-mediated postsynaptic transmission.
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© 2009
Elsevier Inc. Tous droits réservés.
Vol 41 - N° 1
P. 53-56 - juillet 2009 Retour au numéro
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