Vertebral fractures are usually the first to occur in osteoporosis, provide indisputable evidence of reduced bone strength, and are frequently a harbinger of further vertebral and nonvertebral fracture. Radiologists are best placed to draw attention to the presence of vertebral fractures, most of which are clinically silent. Magnetic resonance imaging supplemented if necessary by computed tomography is usually sufficient to enable distinction between osteoporotic and nonosteoporotic vertebral fracture, without a need for percutaneous biopsy.